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Colonic Perforation as Initial Presentation of Amyloid Disease: Case Report and Literature Review

Introduction Amyloidosis is an uncommon disease caused by the deposition of amyloid fibrils in tissues. This disease does not usually require surgical intervention, which could be warranted in the presence of complications such as bleeding, obstruction...
14/03/2024 18:30:00

Orthotopic Liver Transplantation: Surgical Techniques

The authors have chosen to describe the most commonly used surgical techniques for liver transplantation and their variations, namely, the standard technique with and without venous-venous bypass, the piggy-back technique with and without venous-venous...
26/02/2024 16:45:27

Sheep in Wolf’s Clothing: Pedunculated Colonic Lipoma with Overlying Hyperplastic and Ulcerated Epithelium

Lipomas are the most common non-epithelial benign tumors of the gastrointestinal tract with a reported incidence in the colon of 0.2–4.4%. These lesions are usually asymptomatic with a typical endoscopic finding of a smooth, slightly yellow, circular, polyp that is sessile in most cases, covered with normal colonic mucosa.
22/01/2024 19:26:05

From the Laboratory Bench to the Patient’s Bedside: An Update on Clinical Trials With Mesenchymal Stem Cells

The microenvironment of mammalian bone marrow is composed of several different elements that support hematopoiesis and bone homeostasis (Muller-Sieburg and Deryugina, 1995; Zhang et al., 2003). It includes a heterogeneous population of cells...
11/12/2023 19:15:53

Subcapsular Hepatic Hematoma Post- ERCP: Case Report and Review of the Literature

Hepatic hematoma is a rare but possible complication of ERCP. We describe the case of a 75-year old man with a large, 8 × 12 cm, sub-capsular and intra-parenchymal hematoma post ERCP, affecting the right liver segments and treated conservatively.
20/11/2023 19:43:14

Pregnancy after liver and other transplantation

Since the first human liver transplant performed in 1963 by Thomas Starzl, many advances in surgical techniques and immunosuppressive therapy have helped to increase the numbers of women who undergo allogenic organ transplantation each year ...
16/10/2023 19:19:18

Update on Chronic Rejection After Intestinal Transplant: An Overview From Experimental Settings to Clinical Outcomes

Chronic rejection affects the long-term survival of solid-organ transplants, accounting for an incidence of between 5% and 10% after intestinal/multivisceral transplant. Because of unclear symptoms and signs and endoscopic findings, the diagnosis is ...
02/10/2023 18:58:30

Sociodemographic Differences in Early Access to Liver Transplantation Services

The question of whether health care inequities occur before patients with end-stage liver disease (ESLD) are waitlisted for transplantation has not previously been assessed. To determine the impact of gender, race and insurance on access to ...
18/09/2023 18:15:01

A New Technique for Successful Management of a Complete Suprahepatic Caval Transection

In June 2001, a 17-year-old girl was involved in a high-speed motorcycle crash. She was taken to a local hospital, where multiple large, actively bleeding lacerations of the spleen and right lobe of the liver were found. A splenectomy was performed and...
04/09/2023 17:25:18

A Step Backward for Italy’s Meritocracy

ITALIAN SCIENTISTS HAVE LONG LAMENTED THE lack of resources, political attention, and meritocracy in assigning taxpayers’ money...
03/07/2023 18:55:03

Wasting lives: The effects of toxic waste exposure on health. The case of Campania, Southern Italy

Three decades of illegal practices of waste dumping and consequent environmental abuse have made the Campania Region, Southern Italy, a unique case in the context of wasterelated health outcomes. Scientific evidence is mounting in support of a ...
07/06/2023 20:31:30

Umpredictable scientific research n.3: Weaning of immunosuppression in liver transplant recipients

Immunosuppression has been sporadically discontinued by noncompliant liver allograft recipients for whom an additional 4 1/2 years of follow-up is provided
28/05/2023 14:00:00

Umpredictable scientific research n.2: Effect of Donor Age and Sex on the Outcome of Liver Transplantation

We correlated donor and recipient factors with graft outcome in 436 adult patients who underwent 462 liver transplants. Donor variables analyzed were age, gender, ABO blood group, cause of death, length of stay in the intensive care unit...
26/05/2023 14:00:00

Umpredictable scientific research n.1: Treatment of Hepatic Epithelioid Hemangioendothelioma With Liver Transplantation

Ten patients received liver transplants for unresectable epithelioid hemangioendothelioma (EHE). At the time of transplantation, four patients had microscopic metastases to the hilar lymph nodes, and one of the four also had metastases to a ...
24/05/2023 14:00:00

An Abridged Photographic History of Organ Transplantation

Organ transplantation is one of the most remarkable therapeutic advances in modern medicine; it started as an experiment and has become a life-saving practice. We briefly describe the major milestones of this multidisciplinary clinical science...
15/05/2023 17:20:34

International Perspective on Healthcare Sustainability

Healthcare systems vary consistently between countries but most are facingsimilar challenges. The changing medical, demographic, technologicalconditions and the impact of financial and economic austerity create newdemands at a time when the public are...
20/04/2023 17:53:15

Immunosuppression, Compliance, and Tolerance After Orthotopic Liver Transplantation: State of the Art

Orthotopic liver transplantation is the treatment of choice for several otherwise irreversible forms of acute and chronic liver diseases. Early implemented immunosuppressant regimens have had disappointing results with high rejection rates. However ...
24/03/2023 18:19:21

The State of Research in Europe and in Italy: The Risks of Short-Sighted Decisions

Eight years ago we published this commentary, which unfortunately remains sadly topical. Recent events have confirmed that it is urgent and necessary to adopt forward-looking visions rather than deal with emergency solutions.
14/03/2023 19:12:56

Benign Hepatic Tumors and Liver Transplantation: A Literature Review

Management of benign liver tumors represents still an open debate, with no clear guidelines for patient selection, treatment options, and indications to surgical intervention. Usually, most of these diseases are conservatively treated, in view of their lo
08/02/2023 20:13:01

Global Kidney Exchange Transplants

I thought to post a few of our scientific manuscripts to share this important innovative procedure that will help thousands of patients suffering from end-stage kidney disease.
30/01/2023 17:39:16

Spiritual Thinking and Surgery

A doctor’s conduct in his clinical activity, his relationship with the patient, not only serve as a role model for new generations but are all elements that make up his way of being a doctor and they are inevitably influenced by his human nature.
19/01/2023 08:45:00

Baboon-to-human liver transplantation

30 years ago the first baboon-to-human transplant, with my mentor T. E. Starzl. I would like to recall this historic article in the journal "The Lancet" of 9 January 1993
09/01/2023 19:53:04

Open dialogue between professionals with different opinions builds the best policy

Delmonico and Ascher respond to Rees et al, but also to a confidential letter of intent, a work-in-progress draft for a possible grantapplication, which is not a public document and was never meant for distribution. We ask how they would respond ...
11/09/2017 17:59:17

GRG Profiles: Professor Ignazio Marino

Ignazio Marino was born in Genoa, Italy, in 1955 as the son of a naval engineer. His interest in medicine, in particular surgery, began while attending high school as a mean to ‘‘achieve tangible results and life-changing out-comes on patients ...
01/01/2014 18:12:25

Food Price Complexities Require Nuance

KRIPKE TAKES ISSUE WITH THE REFERENCES we cited in our Policy Forum. We based our arguments on a thorough analysis of many reports and communications of all the institutions we discussed, including Oxfam’s (1). For example, a substantive 2008 ...
04/05/2012 18:21:57